This household accommodates only one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was discovered to methylate, legal practice besides histone, numerous non-histone proteins, including p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and parts of the TATA binding protein (TBP) complex, TBP-related elements TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Okay/R-S/T-Okay (goal lysine is bold), can be recognized by the H3K4 demethylase KDM1A/LSD1, which is capable of removing the methyl mark on most of these substrates 17 , ninety four Therefore KMT7/KDM1A has emerged as a basic model for dynamic lysine methylation of each histone and non-histone proteins.

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